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                        ==PSEUDOTUMOR CEREBRI==

5
AUTHOR                    Wandstrat TL
AUTHOR                    Phillips J
TITLE                     Pseudotumor cerebri responsive to
                          acetazolamide
SOURCE                    Ann. Pharmacother.; VOL 29 ISS Mar 1995,
                          P318, (REF 5)
ABSTRACT                  IPA  COPYRIGHT: ASHP  The case of a 14-yr-old
                          girl who developed pseudotumor cerebri (PC)
                          secondary to minocycline therapy for acne
                          that was successfully treated with
                          acetazolamide 500 mg twice daily is reported.
                          The patient presented to her pediatrician's
                          office with a 2-wk history of headache,
                          pounding in both ears and eyes, and a 2-day
                          history of diplopia. She was admitted to the
                          hospital and was diagnosed with PC secondary
                          to minocycline therapy. She was treated with
                          a tapering regimen of dexamethasone and
                          acetazolamide. After a 1-wk hospital stay,
                          the patient was symptom-free and was
                          discharged with a prescription for
                          acetazolamide. At 6, 8, and 12 months after
                          admission, the patient experienced headaches
                          with normal visual fields when attempts were
                          made to wean the acetazolamide. The patient
                          still requires acetazolamide 500 mg twice
                          daily to control headaches. At 12 months
                          there was no evidence of residual PC and it
                          was concluded that the patient's protracted
                          headache may be caused by something other
                          than PC.

7
AUTHOR                    Sullivan HC
TITLE                     Diagnosis and management of pseudotumor
                          cerebri
SOURCE                    J. Natl. Med. Assoc.; VOL 83 ISS Oct 1991,
                          P916-918, (REF 13)
ABSTRACT                  IPA  COPYRIGHT: ASHP  The characteristic
                          features, etiology, diagnosis, signs, and
                          symptoms and treatment of pseudotumor cerebri
                          are discussed. It was noted that the
                          recommended initial therapy should be the
                          reduction of cerebrospinal fluid with
                          acetazolamide. Various diuretics have been
                          used to treat the disease, but no one agent
                          has been found to be more effective than
                          another.

15
AUTHOR                    Lessell S
TITLE                     Pediatric pseudotumor cerebri (idiopathic
                          intracranial hypertension).
SOURCE                    Surv Ophthalmol; VOL 37, ISS 3, 1992, P155-66
                          (REF: 129)
ABSTRACT                  This review focuses on the features of
                          pseudotumor cerebri in the pediatric age
                          group. There is no sex predilection in
                          children, and obesity does not appear to be
                          an important factor. Infants and young
                          children may present with irritability,
                          apathy, or somnolence, rather than headache.
                          Dizziness and ataxia may also occur.
                          Papilledema is infrequently noted in
                          pediatric patients if the fontanelles are
                          open or the sutures are split.
                          Pre-adolescents appear more likely than
                          adults or adolescents to have manifestations
                          of their pseudotumor cerebri other than
                          headache and papilledema, including lateral
                          rectus pareses, vertical strabismus, facial
                          paresis, back and neck pain. Among the
                          etiologies that are particularly pertinent to
                          children are tetracycline therapy,
                          malnutrition or renutrition, and the
                          correction of hypothyroidism. Children with
                          pseudotumor cerebri are at risk for visual
                          loss and their visual function must be
                          closely monitored. Surgical intervention is
                          imperative when vision is threatened.