YOU ARE NOW CONNECTED TO THE TOXLINE (1981 FORWARD, NON-ROYALTY) FILE. ==POLYARTERITIS NODOSA== 5 AUTHOR Guillevin L AUTHOR Fain O AUTHOR Lhote F AUTHOR Jarrousse B AUTHOR Houng DL AUTHOR et al TITLE Lack of superiority of steroids plus plasma exchange to steroids alone in the treatment of polyarteritis nodosa and Churg-Strauss syndrome: prospective, randomized trial in 78 patients SOURCE Arthritis Rheum.; VOL 35 ISS Feb 1992, P208-214, (REF 24) ABSTRACT IPA COPYRIGHT: ASHP A prospective randomized trial was conducted in patients with Churg-Strauss Syndrome or periarteritis nodosa in which 42 patients received 1 mg/kg of oral prednisone daily for one month followed by an elaborate decreasing dosage scheme and 36 patients received prednisone therapy plus 12 plasma exchanges, 60 ml/kg; oral cyclophosphamide 2 mg/kg daily was given in cases of treatment failure. Treatment was stopped in 16 patients because of lack of efficacy. Relapse occurred in 10 patients receiving prednisone and in 8 patients receiving prednisone plus plasma exchange. At the 7 yr follow-up, 27 receiving prednisone and 29 receiving prednisone plus plasma exchange recovered completely. As a second-line treatment, cyclophosphamide reversed disease evolution in 7 of 10 patients not responding to prednisone and in 4 of 6 patients not responding to prednisone plus plasma exchange. It was concluded that combined therapy with prednisone plus plasma exchange is not superior to prednisone alone, and cyclophosphamide as a second-line treatment is effective and well tolerated. 7 AUTHOR Moreland LW AUTHOR Ball GV TITLE Cutaneous polyarteritis nodosa SOURCE Am. J. Med.; VOL 88 ISS Apr 1990, P426-430, (REF 56) ABSTRACT IPA COPYRIGHT: ASHP The cases of 6 patients (aged 15 to 74 yr old) with cutaneous polyarteritis nodosa who were treated with monotherapy or combined therapy with prednisone and a variety of nonsteroidal anti-inflammatory agents, including indomethacin and tolmetin, are reported. 9 AUTHOR Bertch KE AUTHOR Murray S AUTHOR Duarte B AUTHOR Bauman JL TITLE Managing a patient with polyarteritis nodosa SOURCE Hosp. Ther.; VOL 13 ISS Feb 1988, P87-90, 92-93, (REF 10) ABSTRACT IPA COPYRIGHT: ASHP The diagnosis, clinical features, and treatment of periarteritis nodosa are discussed and illustrated in the case of a 33-yr-old man who was treated with cyclophosphamide, 150 mg daily, and prednisone, 80 mg daily. Corticosteroids have long been advocated for the treatment of periarteritis nodosa but more recently these agents have been combined with immunosuppressive drugs, which induce a more prolonged remission and carry lower risk of relapse. 10 AUTHOR Tannenbaum H TITLE Combined therapy with methotrexate and prednisone in polyarteritis nodosa SOURCE Can. Med. Assoc. J.; VOL 123 ISS Nov 8 1980, P893-894, (REF 14) ABSTRACT IPA COPYRIGHT: ASHP A case report in which a 32-yr-old man with polyarteritis nodosa, refractory to high dose steroid (60 mg prednisone/day) therapy, was treated with 25 mg IV methotrexate/week for 18 weeks, is presented. After the course of treatment, the daily prednisone dose was tapered to 20 mg and later on to 10 mg. Intravenous methotrexate is suggested as a useful alternative in patients with severe vasculitis.