YOU ARE NOW CONNECTED TO THE TOXLINE (1981 FORWARD, NON-ROYALTY) FILE. ==HYDROGEN FLUORIDE AND HYPOMAGNESEMIA== 4 AUTHOR Stremski ES AUTHOR Grande GA AUTHOR Ling LJ TITLE Survival following hydrofluoric acid ingestion. SOURCE Ann Emerg Med; VOL 21, ISS 11, 1992, P1396-9 ABSTRACT Systemic toxicity after significant dermal exposure to hydrofluoric acid includes rapid development of hypocalcemia and hyperkalemia, leading to ventricular fibrillation. Similar dysrhythmias have occurred in patients after ingestion of sodium fluoride-containing compounds. Ingestion of hydrofluoric acid could induce similar cardiac toxicity; however, reported cases of hydrofluoric acid ingestion rarely have been described, and the rapid death of these patients has not allowed verification of this hypothesis. On two separate occasions, a 70-year-old woman ingested up to 2 oz of a 8% hydrofluoric acid-containing solution. Recurrent ventricular fibrillation with concurrent hypocalcemia and hypomagnesemia complicated her first episode, whereas a more aggressive administration of calcium and magnesium may have prevented dysrhythmias in the second episode. Survival from ventricular fibrillation after hydrofluoric acid ingestion has not been reported previously and suggests a role for aggressive empiric calcium and magnesium replacement. 1 AUTHOR KLASNER AE AUTHOR SCALZO AJ AUTHOR BLUME C AUTHOR JOHNSON P AUTHOR THOMPSON MW TITLE Marked hypocalcemia and ventricular fibrillation in two pediatric patients exposed to a fluoride-containing wheel cleaner. SOURCE ANNALS OF EMERGENCY MEDICINE; 28 (6). 1996. 713-718. ABSTRACT BIOSIS COPYRIGHT: BIOL ABS. In two separate cases, pediatric patients exposed to Armor-All Quicksilver Wheel Cleaner exhibited systemic toxicity including mental status changes, marked hypocalcemia, and ventricular fibrillation. One child also demonstrated profound hypomagnesemia. These are the first pediatric reports of near-fatal outcomes after ingestion or inhalation of a hydrofluoric acid-like product, namely, ammonium bifluoride. YOU ARE NOW CONNECTED TO THE TOXLINE65 (1965 - 80, NON-ROYALTY) FILE. 1 AUTHOR Tepperman PB TITLE Fatality due to acute systemic fluoride poisoning following a hydrofluoric acid skin burn. SOURCE J Occup Med; VOL 22, ISS 10, 1980, P691-2 ABSTRACT Reports indicate that death due to hydrofluoric acid exposure is usually the result of inhalation of vapor causing pulmonary edema and fluoride poisoning. Absorption via the skin route of fluoride ion sufficient to cause serious systemic problems and even death has rarely been reported. A fatality resulting from a severe facial burn, which produced acute systemic fluoride poisoning with profound hypocalcemia and hypomagnesemia, is presented. The importance of proper personal protective equipment as well as the immediate initiation of first aid and appropriate medical measures, including the monitoring and replacement of serum calcium and magnesium, are emphasized. 2 AUTHOR EGYED MN AUTHOR SHLOSBERG A TITLE Acute sodium fluorosilicate poisoning in domestic animals with special reference to sheep. SOURCE FLUORIDE; 8 (3). 1975 134-143 ABSTRACT HEEP COPYRIGHT: BIOL ABS. An account is given of 27 field cases of sodium fluorosilicate poisoning in domestic animals. Detailed clinical, chemical, biochemical and pathological findings are given in acute experimental fluorosilicate poisoning in sheep. Mild symptoms occurred following a dose of 25 - 50 mg/kg and the sheep recovered 3 - 5 days later. From 200 mg/kg more severe symptoms were produced leading to death of the sheep ofn the 6th day of poisoning. Dosages of 1.5 and 2.0 g/kg fluorosilicate were fatal 3 and 2.5 h, respectively, after the sheep were given the poison. Marked hypocalcemia, hypomagnesemia and increased blood sugar and elevation of blood P and various serum enzymes (glutamate oxaloacetate transaminase, lactate dehydrogenase, isocitric dehydrogenase), were the most significant findings in fatal poisonings. Fluoride values in blood serum and urine were determined at various stages of poisoning.