YOU ARE NOW CONNECTED TO THE TOXLINE (1981 FORWARD, NON-ROYALTY) FILE. ==FALLOPIAN TUBE CANCER== 3 AUTHOR Behr J AUTHOR Thyselius D AUTHOR Jager W AUTHOR Paterok EM TITLE [Primary metastasizing fallopian tube carcinoma. Case report and overview of current therapy] SOURCE Zentralbl Gynakol; VOL 112, ISS 23, 1990, P1477-80 (REF: 20) ABSTRACT Case report a primary metastasizing carcinoma of the fallopian tube with radical operation and 4 cycles of antineoplastic chemotherapy (cisplatin and treosulfan). Tumor markers decreased to normal level following primary treatment and the first chemotherapy cycle. After six months we did and immunoscintigraphy and second-look-laparotomy including the Regaj-procedure. There was a histological complete remission. Additionally we give a review about cytostatic treatment of this cancer the last then years. Radical operation combined with adjuvant chemotherapy is said to be successful. 17 AUTHOR Peters WA 3d AUTHOR Andersen WA AUTHOR Hopkins MP TITLE Results of chemotherapy in advanced carcinoma of the fallopian tube. SOURCE Cancer; VOL 63, ISS 5, 1989, P836-8 ABSTRACT Forty-six patients with measurable disease received chemotherapy for advanced primary or recurrent carcinoma of the fallopian tube. The response rate was 9% with single-agent therapy, 29% with multiagent therapy without cisplatin, and 81% with cisplatin-containing combination therapy. Survival was significantly improved in Stage III/IV with the addition of cisplatin-based combination therapy. 20 AUTHOR Maxson WZ AUTHOR Stehman FB AUTHOR Ulbright TM AUTHOR Sutton GP AUTHOR Ehrlich CE TITLE Primary carcinoma of the fallopian tube: evidence for activity of cisplatin combination therapy. SOURCE Gynecol Oncol; VOL 26, ISS 3, 1987, P305-13 ABSTRACT The records of 23 patients with confirmed carcinoma of the fallopian tube, treated between 1966 and 1983, were reviewed. Patients ranged in age from 41 to 88 years. A pelvic mass was the most common preoperative finding (61%), followed by abnormal bleeding (43%), and pain (39%). Fifteen patients had stage I or II disease, 8 had Stage III or IV disease. In patients with metastatic disease, involvement of the peritoneal surfaces, bowel, and omentum were noted most often. Lymph nodes were the most common site(s) of recurrent disease. Twelve evaluable patients with measurable disease were treated with cisplatin and cyclophosphamide (PC) +/- doxorubicin (PAC). There were 9 complete and 2 partial responses, a 92% response rate. Incorporation of cisplatin therapy appears to have resulted in improved short-term survival. 23 AUTHOR Deppe G AUTHOR Zbella E AUTHOR Friberg J AUTHOR Thomas W TITLE Combination chemotherapy for mixed mullerian tumor of the Fallopian tube. SOURCE Cancer; VOL 54, ISS 8, 1984, P1517-20 ABSTRACT A patient with mixed mullerian tumor of the fallopian tube was treated with cyclophosphamide and cisplatin. The regimen achieved a complete remission. No severe drug-related toxicity occurred. YOU ARE NOW CONNECTED TO THE MEDLINE (1994 - 97) FILE. 2 AUTHOR Horn LC AUTHOR Werschnik C AUTHOR Bilek K AUTHOR Emmert C TITLE Diagnosis and clinical management in malignant Mullerian tumors of the fallopian tube. A report of four cases and review of recent literature. SOURCE Arch Gynecol Obstet 1996;258(1):47-53 ABSTRACT Four out of 42 cases of primary tubal malignancy diagnosed in our histopathological laboratory were malignant mixed Mullerian tumors (MMMT). All four patients were postmenopausal with a mean age of 66.5 years at diagnosis. A correct preoperative diagnosis was made only in one case. Tumor staging (FIGO) revealed stage IIa, IIIc and IV. One patient died of postoperative pulmonary embolism, a second patient of an unknown cause five month after surgery and a third patient died of disease after 11 months with secondary deposits in pelvic peritoneum, omentum and paraaortic lymph nodes. The fourth patient is still alive. One patient received chemotherapy alone, one by radiation and chemotherapy and two patients by radiation alone. Tumor spread at the time of diagnosis and the residual tumor volume were the most important prognostic factors. All tumors were histologically the homologous type of MMMT (carcinosarcomas). No heterologous elements were found. Metastatic tumors showed only sarcomatous elements. 3 AUTHOR Jereczek B AUTHOR Jassem J AUTHOR Kobierska A TITLE Primary cancer of the fallopian tube. Report of 26 patients. SOURCE Acta Obstet Gynecol Scand 1996 Mar;75(3):281-6 ABSTRACT BACKGROUND: Due to rarity of fallopian tube cancer most series on this tumor are small and many problems have remained unsolved. The aim of this report is to review our experience with this neoplasm and to compare it with previously published data. METHODS: Retrospective study of 26 patients with fallopian tube cancer treated in one institution between 1974 and 1994. All patients underwent primary surgical treatment and 18 received adjuvant therapy including pelvic irradiation in 14 cases and chemotherapy in four. RESULTS: Relapse occurred in 18 out of 25 followed up patients. Upper abdominal component of relapse was encountered in 12 patients (67%), pelvic component - in eight (44%) and extraperitoneal component - six (33%). Pelvic relapse occurred in two out of 13 followed up patients treated with postoperative irradiation and in six out of 12 who did not receive postoperative radiotherapy. Survival ranged from 6 to 218+ months (median 23 months). Five-year actual survival was 33%. There were no 2-year survivors in patients presenting with stage II-IV disease. No correlation was found between tumor grade and survival. CONCLUSIONS: Fallopian tube cancer is a treatable disease but cure can be only achieved in patients with early tumor. Postoperative radiotherapy may result in better local control but does not preclude extrapelvic dissemination, therefore adjuvant chemotherapy should be considered in high risk patients. Registration of all new cases as well as prospective multicenter studies are warranted to establish optimal management.