YOU ARE NOW CONNECTED TO THE TOXLINE (1981 FORWARD, NON-ROYALTY) FILE. ==ERYTHEMA NODOSUM OF LEGS== 1 TITLE New uses of thalidomide. SOURCE Med Lett Drugs Ther 1996 Feb 16;38(968):15-6 ABSTRACT Thalidomide is now available as an investigational drug in the USA. A synthetic derivative of glutamic acid, it was marketed in Europe in 1957 as a sedative but withdrawn four years later after being associated with severe human teratogenicity (PF D'Arcy and JP Griffin, Adverse Drug React Toxicol Rev, 13:65, 1994). The drug has since been found effective for several different indications. 6 AUTHOR Sampaio EP AUTHOR Kaplan G AUTHOR Miranda A AUTHOR Nery JA AUTHOR Miguel CP AUTHOR Viana SM AUTHOR Sarno EN TITLE The influence of thalidomide on the clinical and immunologic manifestation of erythema nodosum leprosum. SOURCE J Infect Dis; VOL 168, ISS 2, 1993, P408-14 ABSTRACT Immunologic and clinical manifestations of erythema nodosum leprosum (ENL) and their response to thalidomide therapy were evaluated. Circulating tumor necrosis factor-alpha (TNF alpha) levels were assayed in serum obtained from lepromatous leprosy patients at diagnosis, during multidrug therapy, at the onset of ENL episodes, and during treatment with thalidomide. Patients with systemic ENL demonstrated the highest serum TNF alpha levels, which decreased significantly during thalidomide treatment. Serum TNF alpha in nonreactional patients was associated with mild flu-like symptoms and local inflammatory lesions. Serum interferon-gamma (IFN-gamma) was also elevated in patients with high TNF alpha levels. Thalidomide therapy reduced not only serum TNF alpha levels and the clinical symptoms but also the dermal infiltration of polymorphonuclear leukocytes and T cells. The expression of intercellular adhesion molecule 1 and major histocompatibility complex class II antigens on the epidermal keratinocytes was also down-regulated. These results indicate that the thalidomide-induced alleviation of clinical symptoms of ENL was associated with a reduction of TNF alpha levels. 4 AUTHOR Artola Aizalde E AUTHOR Gorrotxategui Gorrotxategui P AUTHOR Lopez Palma F AUTHOR Guerrero Pereda R AUTHOR Unanue Tejera G AUTHOR Palacio Pina M AUTHOR Albisu Andrade Y TITLE [Erythema nodosum in pediatric patients. A study of 22 cases] SOURCE An Esp Pediatr; VOL 39, ISS 3, 1993, P191-3 ABSTRACT In this study we report the cases of 22 pediatric patients with nodal erythema. The predominance of this condition in male patients was clear. Etiological factors were determined in 77% of the patients. In our series, the principal cause was tuberculosis (36%). We would like to point out the etiological diversity in this small series of children: streptococcal infection, gastrointestinal infection with Salmonella enteritidis or Campylobacter jejuni, cat scratch disease, infectious mononucleosis, chronic hepatitis B, Crohn's disease and pharmacological (amoxycillin). In 22% of the cases no cause was found. 7 AUTHOR de Almeida Prestes C AUTHOR Winkelmann RK AUTHOR Su WP TITLE Septal granulomatous panniculitis: comparison of the pathology of erythema nodosum migrans (migratory panniculitis) and chronic erythema nodosum. SOURCE J Am Acad Dermatol; VOL 22, ISS 3, 1990, P477-83 ABSTRACT Fifty-eight cases of septal granulomatous panniculitis were reviewed; 14 cases were diagnosed as erythema nodosum migrans (migratory panniculitis) and 36 as chronic erythema nodosum on the basis of clinical and histopathologic features. Erythema nodosum migrans was characterized by markedly thickened and fibrotic septae, marked capillary proliferation (like granulation tissue), and massive granulomatous reaction (with giant cells) along the borders of the widened septa. Hemorrhage was rare, and phlebitis was not seen. Chronic erythema nodosum showed mild septal change, little fibrosis, and lymphohistiocytic perivascular inflammation with only focal granulomatous formation. Phlebitis and hemorrhage were common. The condition termed erythema nodosum migrans has many of the same clinical features as chronic erythema nodosum, and we think this term is preferable to migratory panniculitis. We believe that there are sufficient clinical and histopathologic features to justify considering erythema nodosum migrans as a unique clinicopathologic entity. 8 AUTHOR Tareev EM AUTHOR Kornev BM AUTHOR Moiseev SV TITLE [Erythema nodosum in the clinical picture of internal diseases] SOURCE Ter Arkh; VOL 58, ISS 6, 1986, P36-9 ABSTRACT A study of 64 patients with erythema nodosum (EN), including 53 females, showed sarcoidosis diagnosed in 65% of the cases to be the principal cause of EN. It was followed by drug disease (10%), tuberculosis (3%), pregnancy or labor (5%), tumors (3%) and other underlying diseases (Behcet's diseases, streptococcal infection, histoplasmosis, nonspecific aorto-arteritis, chronic active hepatitis). The cause of EN could not be identified in 5% of patients only. Two or three possible etiologic factors were identified in 17%. Sarcoidosis combined with EN regressed without treatment in 82% of cases. Corticosteroid therapy was only given in cases of pulmonary lesion or other systemic manifestations. Purposeful investigation is believed to be capable of establishing etiology of EN in virtually all cases. 1 AUTHOR Ricci RM AUTHOR Deering KC TITLE Erythema nodosum caused by omeprazole. SOURCE Cutis; VOL 57, ISS 6, 1996, P434 ABSTRACT We report a case of erythema nodosum caused by omeprazole. This side effect of omeprazole has not been previously reported. A 35-year-old white woman developed multiple tender erythematous nodules over the anterior aspect of her upper and lower extremities, fever, malaise, and edema. Her symptoms resolved with withdrawal of all preexisting medications and conservative treatment. Her symptoms flared soon after a rechallenge with omeprazole. A thorough history, physical examination, laboratory evaluation, and roentgenogram failed to reveal another cause for erythema nodosum. It is clear from the rechallenge that this patient's erythema nodosum was caused by omeprazole. We consider that omeprazole should be added to the list of medications known to cause erythema nodosum. 4 AUTHOR Okamoto H AUTHOR Mizuno K AUTHOR Imamura S AUTHOR Nagai S AUTHOR Izumi T TITLE Erythema nodosum-like eruption in sarcoidosis. SOURCE Clin Exp Dermatol; VOL 19, ISS 6, 1994, P507-10 ABSTRACT Two cases of sarcoidosis with tender, erythematous nodules on the legs are reported. The cutaneous lesions were clinically similar to those of erythema nodosum, but histologically showed non-caseating epithelioid granulomas. A review of 14 cases of this particular sarcoid eruption reported in Japan showed that 13 had ocular involvement as in our cases. In the light of the high frequency of ocular involvement, a skin biopsy should be considered in patients presenting with erythema nodosum-like eruptions situated on the legs.