YOU ARE NOW CONNECTED TO THE TOXLINE (1981 FORWARD, NON-ROYALTY) FILE. ==CYTOMEGALOVIRUS AND MONONUCLEOSIS== 1 AUTHOR Heyries L AUTHOR Perreard M AUTHOR Monges D AUTHOR Chrestian MA AUTHOR Gerolami A TITLE [Hepatic granulomatosis associated with mononucleosis syndrome secondary to cytomegalovirus infection: apropos of 2 cases in healthy adults] SOURCE Rev Med Interne; VOL 15, ISS 11, 1994, P744-6 ABSTRACT In this study, the authors report two observations of granulomatous hepatitis. The secondary appearance of a mononucleosis syndrome, three weeks after the onset of fever, in healthy adults, evoked the diagnosis of a cytomegalovirus infection. The authors insist on the histologic and virologic differences of the CMV infection between the healthy adults and the immunodepressed patients. They also note the difficulties of the diagnosis of the CMV infection in healthy adults. YOU ARE NOW CONNECTED TO THE MEDLINE (1994 - 97) FILE. 4 AUTHOR Patrzalek M AUTHOR Krzy~zanowska H TITLE [Infectious mononucleosis with IgM antibodies against cytomegalovirus] SOURCE Przegl Epidemiol 1995;49(4):385-9 ABSTRACT In four of studied children (age 3-12 yrs) with serologically confirmed infectious mononucleosis we found IgM antibodies to CMV. This can be explained by coincidence of both infections or by nonspecific stimulation of B lymphocytes in the course of mononucleosis. Disappearance of IgM antibodies to CMV after 3 months, and concomitant presence of IgG antibodies after 6 months suggests the former. 9 AUTHOR Coll I AUTHOR Sanchez C AUTHOR Sierra M AUTHOR Lite J AUTHOR Garau J TITLE [Spontaneous mononucleosis caused by cytomegalovirus in the immunocompetent adult] SOURCE Enferm Infecc Microbiol Clin 1995 Apr;13(4):224-8 ABSTRACT BACKGROUND: The first Spanish series of spontaneous infectious mononucleosis (IM) by cytomegalovirus (CMV) in immunocompetent adults is reported. METHODS: Patients whose clinical manifestations, physical exam, analysis and serology were compatible with acute CMV infection from 1984 to 1993 were retrospectively reviewed. RESULTS: Thirty patients with a mean age of 36 years fulfilled the diagnostic criteria. All presented fever, alone or associated with other symptoms, with a mean duration of 18 days, which persisted over 3 weeks in 36%. Physical exam showed lymph node enlargement (50%), hepatomegaly (33%), splenomegaly (20%) and was normal in 8 patients (26%). Mean leukocyte count was 9.75 x 10(9) (+/- 4.63 x 10(9) with more than 50% lymphomonocytic cells in 22 patients (76%) and reactive lymphocytes, principally from the outset, although this was observed on days 2 and 60 in 11 cases (36%). LDH, ASAT and ALAT were moderately elevated and ESR was normal. Serologic diagnosis was established from IgM (13%) seroconversion or positive IgM in the two samples with IgG four-fold increase (23%), as well as the presence of positive IgM and invariable high IgG in both determinations (26%) or all IgM positive titers in a single sample (36%). CONCLUSIONS: Infectious mononucleosis by cytomegalovirus is an infrequently diagnosed disease which should be considered in any young patient with fever despite a little demonstrative initial physical exam absence of atypical lymphocytes or a lack of diagnostic serology. 16 AUTHOR Lajo A AUTHOR Borque C AUTHOR Del Castillo F AUTHOR Martin-Ancel A TITLE Mononucleosis caused by Epstein-Barr virus and cytomegalovirus in children: a comparative study of 124 cases. SOURCE Pediatr Infect Dis J 1994 Jan;13(1):56-60 ABSTRACT We present 124 children who had mononucleosis. The patients were selected according to strict clinical features. Twenty (16.1%) of the 124 children were proved to have cytomegalovirus mononucleosis and 104 (83.8%) children had Epstein-Barr virus mononucleosis. The symptoms were similar in both groups. Significant differences were found only for the presence of cervical lymphadenopathy, which was more frequent in the Epstein-Barr group (83.2%) compared with the cytomegalovirus group (75%). Fever was the most frequent symptom in both groups. Cytomegalovirus mononucleosis was significantly more frequent in children younger than 4 years.