YOU ARE NOW CONNECTED TO THE TOXLINE (1981 FORWARD, NON-ROYALTY) FILE. ==COLD URTICARIA== 2 AUTHOR Husz S AUTHOR Toth-Kasa I AUTHOR Kiss M AUTHOR Dobozy A TITLE Treatment of cold urticaria. SOURCE Int J Dermatol; VOL 33, ISS 3, 1994, P210-3 ABSTRACT BACKGROUND. The etiology of cold contact urticaria is unknown and the therapy is therefore usually rather disappointing. METHODS. This study reports therapeutic data on 42 patients with cold urticaria treated with a combination of terbutaline (3 x 5 mg a week, later 3 x 2.5 mg) and aminophylline-containing drugs (3 x 150 mg). RESULTS. Complete remission of the urticarial response was achieved in 37 of the 42 patients. CONCLUSIONS. The therapy was tolerated relatively well and the results are promising. 9 AUTHOR Villas Martinez F AUTHOR Contreras FJ AUTHOR Lopez Cazana JM AUTHOR Lopez Serrano MC AUTHOR Martinez Alzamora F TITLE A comparison of new nonsedating and classical antihistamines in the treatment of primary acquired cold urticaria (ACU). SOURCE J Investig Allergol Clin Immunol; VOL 2, ISS 5, 1992, P258-62 ABSTRACT The efficacy of the new nonsedating antihistamines loratadine and cetirizine was compared in a randomized, single-blind, crossover, controlled study with that of the classical antihistamines cyproheptadine and ketotifen in seven patients with primary acquired cold urticaria (ACU). The patients received each of the four drugs for 14 consecutive days with a 7-day interval between drugs. We evaluated clinical symptomatology, adverse effects, minimum time of cold contact stimulation required to induce an immediate coalescent wheal (CSTT), and inhibition of histamine-induced wheal response. Both loratadine and cetirizine showed suppression of symptoms with infrequent adverse effects. Important side-effects were observed in patients receiving cyproheptadine. Improvement in CSTT was statistically significant for all drugs compared with baseline values, without differences among them. The histamine-induced skin test was significantly inhibited by all antihistamines. Wheal reductions were 34.6% for loratadine and 50.9% for cetirizine. This study suggests that both loratadine and cetirizine may be effective in the treatment of primary ACU. 14 AUTHOR Neittaanmaki H AUTHOR Fraki JE AUTHOR Gibson JR TITLE Comparison of the new antihistamine acrivastine (BW 825C) versus cyproheptadine in the treatment of idiopathic cold urticaria. SOURCE Dermatologica; VOL 177, ISS 2, 1988, P98-103 ABSTRACT A double-blind, crossover trial with a new triprolidine derivative, acrivastine (BW 825C; 8 mg 3 times daily), cyproheptadine (4 mg 3 times daily) and placebo was carried out in 18 patients suffering from idiopathic cold urticaria. Acrivastine and cyproheptadine significantly (p less than 0.01) reduced weal areas following ice cube challenge when compared to placebo. Acrivastine was found to be significantly more effective (p less than 0.01) than cyproheptadine in reducing weal areas. Furthermore, cyproheptadine caused significantly more drowsiness than acrivastine (p = 0.021) or placebo (p = 0.013), which did not differ from each other. This study shows that acrivastine is an effective agent in the treatment of cold urticaria and suggests that acrivastine in the dose used lacks adverse effects, such as drowsiness, traditionally associated with antihistamine therapy. 18 AUTHOR Neittaanmaki H AUTHOR Myohanen T AUTHOR Fraki JE TITLE Comparison of cinnarizine, cyproheptadine, doxepin, and hydroxyzine in treatment of idiopathic cold urticaria: usefulness of doxepin. SOURCE J Am Acad Dermatol; VOL 11, ISS 3, 1984, P483-9 ABSTRACT Randomized double-blind trials using doxepin and several conventional antihistamines were carried out for treatment of patients with idiopathic cold urticaria. In the first double-blind trial, eight of nine patients preferred doxepin (10 mg three times daily) to cinnarizine (10 mg three times daily). In the second double-blind trial, the results of ice cube tests suppressing the effect of cyproheptadine (4 mg three times daily), doxepin (10 mg three times daily), and hydroxyzine (10 mg three times daily) did not statistically differ. However, doxepin was subjectively the most effective and it had fewer side effects than other treatments that were compared. Doxepin effectively suppressed the wheal and itching responses and shortened the duration of the wheal response in the ice cube test in all patients with cold urticaria who were studied. 22 AUTHOR Kobza Black A AUTHOR Keahey TM AUTHOR Eady RAJ AUTHOR Greaves MW TITLE Dissociation of histamine release and clinical improvement following treatment of acquired cold urticaria by prednisone SOURCE Br. J. Clin. Pharmacol.; VOL 12 ISS Sep 1981, P327-331, (REF 19) ABSTRACT IPA COPYRIGHT: ASHP The effect of prednisone (I) in oral doses of 20 or 25 mg daily for 1-5 days, on cold evoked histamine release and clinical response was studied in 6 patients with acquired cold urticaria. Following cold challenge all 6 patients developed an immediate urticarial response of the forearm and elevation of histamine levels, measured by superfusion cascade bioassay of the venous blood draining the forearm. After treatment with I, a suppression of evoked histamine release occurred in all but one patient. However, there was no corresponding decrease of erythema or edema, though pruritus was improved in most patients. It was suggested that because of the lack of clinical improvement in erythema and edema, despite reduction in histamine levels, histamine may not be the principal mediator of the vascular response to cold challenge in acquired cold urticaria. 1 AUTHOR Cooke RA TITLE Essential Acquired Cold Urticaria: Stimulated Only by Systemic as Well as Local Cooling SOURCE Occupational Medicine, Vol. 46, No. 2, pages 157-158, 9 references, 1996 ABSTRACT A case of essential acquired cold urticaria in a management worker was reported. The patient was a 22 year old male who presented with a diffuse scaly rash on the dorsal aspect of both hands with areas of telangiectasia and skin atrophy and an excoriated red scaly rash on the legs and trunk that began soon after beginning work in a food processing company. The patient reported a long history of eczema and the use of topical steroids. Following discontinuation of the steroid cream the rash persisted. A clear acute urticarial rash was recognized a few months later during a cold spell of weather when the patient was coincidentally transferred to work in a chilled part of the factory. The patient then reported that his rash had always worsened in the winter. Pronounced urticaria was induced by a cold provocation test and a diagnosis of cold urticaria was made. Treatment with H1 and H2 blockers had little immediate effect but resolution of symptoms gradually occurred after he transferred back to a warm area at work. A repeat cold provocation test, at a time when the external ambient temperature was 7 degrees-C warmer than it had been during the first test, was negative. 7 AUTHOR Edge JA AUTHOR Osborne JP TITLE Terbutaline and ketotifen in cold urticaria in a child SOURCE J. R. Soc. Med.; VOL 82 ISS Jul 1989, P439-440, (REF 8) ABSTRACT IPA COPYRIGHT: ASHP Objective and subjective assessments of terbutaline (I) 3 mg 3 times daily, ketotifen (II) 1 mg 2 times daily or combined therapy are presented for a 9-yr-old girl with a 5 yr history of cold induced urticaria. Both drugs improved symptoms and abolished whealing and flare induced by an ice cube held against the flexor surface of the right forearm for 4 min. Potential mechanisms for the drug actions are discussed. 9 AUTHOR Burns MR AUTHOR Schoch DR AUTHOR Grayzel AI TITLE Cold urticaria and an oral contraceptive SOURCE Ann. Intern. Med.; VOL 98 ISS Jun 1983, P1025-1026, (REF ) ABSTRACT IPA COPYRIGHT: ASHP A case was described in which a 19-yr-old woman developed cold urticaria associated with an oral contraceptive containing one mg of norethindrone and 35 mcg of mestranol. Symptoms disappeared within 2 weeks following discontinuation of the oral contraceptive, despite cold weather. No other treatment was given. It was suggested that the symptoms were induced by the oral contraceptive, although a definite causal relationship was not established. 2 AUTHOR Hausser M AUTHOR Ippen H TITLE [Swimming pool dermatoses] SOURCE Hautarzt; VOL 36, ISS 8, 1985, P436-40 (REF: 44) ABSTRACT Diseases of the skin related to the use of swimming pools do not appear very often in medical reports. In this review of such diseases we designate changes in the skin and hair as being infectious, toxic or allergic in origin. Particular attention is given to allergenic additives in the water. There is no indication that public swimming pools in the Federal Republic of Germany present any danger to the skin.