YOU ARE NOW CONNECTED TO THE TOXLINE (1981 FORWARD, NON-ROYALTY) FILE. ==CHORIOCARCINOMA== 6 AUTHOR Tomoda Y AUTHOR Ishizuka T AUTHOR Gotoh S AUTHOR Furuhashi Y AUTHOR Inoue T TITLE [Recent advances in the treatment of choriocarcinoma] SOURCE Gan To Kagaku Ryoho; VOL 15, ISS 6, 1988, P1833-9 (REF: 20) ABSTRACT Recent advances in intensive care procedures have improved the therapeutic results of choriocarcinoma treatment. The mortality of patients with choriocarcinoma, which was 100% in 1958, has gradually decreased, and finally fell to about 10% in 1983. These favorable results have been mainly due to the progress made in chemotherapy, including combined administration of methotrexate and actinomycin-D. However, recent progress has been chiefly dependent on intensive care procedures, involving so-called multidisciplinary treatment, including surgical treatment for pulmonary or intracranial metastatic foci and whole-brain irradiation. When the treatment results for choriocarcinoma were compared between metastatic and non-metastatic cases, the mortality, which had decreased for both groups with time, had already reached 0% in non-metastatic cases, although it was still about 20% in metastatic cases. These results have made it clear that the most important aspect is how to treat choriocarcinoma metastatic foci. With the goal of finding some form of treatment that will help to attain complete cure of choriocarcinoma, we present here details of recent progress made in choriocarcinoma treatment. 7 AUTHOR Bagshawe KD TITLE Treatment of high-risk choriocarcinoma. SOURCE J Reprod Med; VOL 29, ISS 11, 1984, P813-20 (REF: 28) ABSTRACT Risk has different meanings even within the confines of trophoblastic disease. One unquantifiable risk for patients is treatment by physicians or surgeons with limited knowledge of this rare disease and its modern management. Risk can be immediate at the time of presentation because the disease has sometimes progressed to a life-threatening state before the diagnosis is established. Special problems at that time need consideration on the basis of which organs are involved. Placental-site trophoblastic disease presents distinctive features and requires different management. A major long-term risk is drug resistance, and a high proportion of late treatment failures in choriocarcinoma arise from inappropriate therapy at an early stage in treatment. "Prognostic," or "risk," scoring identifies the propensity of a tumor to become resistant to chemotherapy and enables treatment to be planned from the outset to minimize that risk. 4 AUTHOR Guo WD AUTHOR Chow WH AUTHOR Li JY AUTHOR Chen JS AUTHOR Blot WJ TITLE Correlations of choriocarcinoma mortality with alcohol drinking and reproductive factors in China. SOURCE Eur J Cancer Prev 1994 Mar;3(2):223-6 ABSTRACT This country-based correlation study examined associations of choriocarcinoma mortality with reproductive characteristics and lifestyle factors using data from an ecological survey in 49 Chinese rural counties. Univariate correlation and multivariate regression analyses showed that choriocarcinoma mortality rates among Chinese women were significantly related to alcohol consumption, number of pregnancies and age at menopause, and inversely associated with age at first birth. No clear association was seen between choriocarcinoma mortality and smoking, body mass index, dietary factors and levels of serum nutrients, sex hormones, and antibodies to herpes simplex virus. Limitations of these ecological data preclude causal inferences, but the findings add to the limited evidence of the role of reproductive characteristics in choriocarcinoma risk and provide additional clues to other risk factors for this rare and seldom examined cancer.